Under zero and reverse bias voltage, the photoresponse of these d

Under zero and reverse bias voltage, the photoresponse of these diodes is solely due to the photovoltaic effect in the GaSb depletion region. For forward bias voltages >400 mV, we also observed a photoconductive response from

the InAsSb layer. The proposed physical mechanism is quite different from the one suggested in a recent paper.”
“Background-Matrix metalloproteinases (MMPs) play a key role in cardiovascular disease, in particular aneurysm formation and plaque rupture. Surprisingly, little is known about MMP substrates in the vasculature.

Methods and Results-We used a proteomics approach to identify vascular substrates for 3 MMPs, 1 of each of the 3 major classes of MMPs: Human arteries were incubated with MMP-3 ALK inhibitor (a member of stromelysins), MMP-9 (considered a gelatinase), and MMP-14 (considered a member of the collagenases and of the membrane-bound MMPs). Candidate substrates were identified by mass spectrometry based on increased release from the arterial tissue on digestion, spectral evidence for proteolytic degradation after gel separation, and identification of nontryptic cleavage sites. Using this approach, novel candidates were identified, including extracellular matrix proteins associated with the basement membrane, elastic fibers (emilin-1), and other extracellular proteins (periostin, tenascin-X). Seventy-four nontryptic cleavage sites were detected, many of www.selleckchem.com/products/ABT-263.html which were shared among different MMPs. The proteomics

findings were validated by immunoblotting and by digesting recombinant/purified Volasertib solubility dmso proteins with exogenous MMPs. As proof-of-principle, results were related to in vivo pathology by searching for corresponding degradation products in human aortic tissue with different levels of endogenous MMP-9.

Conclusions-The application of proteomics to identify

MMP targets is a new frontier in cardiovascular research. Our current classification of MMPs based on few substrates is an oversimplification of a complex area of biology. This study provides a more comprehensive assessment of potential MMP substrates in the vasculature and represents a valuable resource for future investigations. (Circ Cardiovasc Genet. 2013;6:106-117.)”
“The rates of change of polymer properties (glass transition temperature, weight fraction sorbed water, and polymer molecular weight) were determined in Poly (DL-lactide-co-glycolide) films under accelerated storage conditions. Films were stored at 70 degrees C and 95%, 75%, 60%, 45%, or 28% relative humidity. Weight fraction sorbed water was determined by thermogravimetric analysis, the glass transition temperature (Tg(mix)) of the polymer/water mixture by modulated temperature differential scanning calorimetry, and PLGA number-average molecular weight (M(n)) by size exclusion chromatography (SEC). Rates of moisture increase and Tg(mix) decrease were related to the decrease in PLGA M(n) through a modification of the Gordon-Taylor equation.

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