Using pore-network modeling and characterization, we have shown that it is possible to tune the porous geopolymer microstructure and the resulting molecular diffusion coefficients of drugs incorporated in this structure to span over two orders in magnitude [10]. It has also been shown that Fentanyl was released at a considerably higher rate under low pH conditions (pH 1; mimicking acidic stomach conditions) as compared

to neutral pH (pH 6.8 mimicking small intestine conditions), which was partly related to the higher solubility of Fentanyl at low pH [5]. Apart from an increased drug solubility at low pH, geopolymer degradation was also believed to be a contributing cause of the increased Fentanyl release rate [5], a problem that is also present for HTS assay other clay-based delivery vehicles

[11]. Geopolymers are depolymerized [7] in acidic media in a process where the charge balancing cations (Na+) in the geopolymer framework are replaced by H+ or H3O+ ions from the solution along with an electrophilic attack by acid protons selleck inhibitor on the polymeric silalate Si–O–Al and siloxo Si–O–Si bonds. The ejection of tetrahedral alumina and silanol species have been observed [12] to be followed by immediate formation of new phases, such as zeolites and gypsum crystals [7] and [13]. The aim of the work is to investigate the influence of incorporating different polymer excipients in pellets made of one geopolymer formulation on the mechanical strength as well as on the release behavior of Zolpidem from the same. Zolpidem is chosen as the model drug in this study due to safety considerations during handling; it is considerably less potent than the physico-chemically similar and highly potent Fentanyl [5]. Kaolin

(Al2Si2O5(OH)4), Farnesyltransferase fumed silica (SiO2, 7 nm particle size), reagent grade sodium hydroxide (NaOH) (Sigma-Aldrich, Stockholm, Sweden) and Zolpidem tartrate (C19H21N3O, Cambrex AB, USA) were used as received. The investigated polymer excipients were Kollicoat MAE 100P (BASF, Luwigshafen, Germany), Poly(ethylene glycol) (#81300, Sigma-Aldrich, Stockholm, Sweden), Protanal L10/60 and L10/60 LS with a high (Gc≈70%) and low (Gc≈40%) guluronic acid content Gc, respectively (kindly donated by the FMC biopolymer, Norway). In addition, the polymer excipient Eastman CAP (Eastman Chemical Company, USA) was briefly tested and discarded. Important polymer excipient characteristics are as summarized in Table 1. Metakaolin (Al2O3·2SiO2) was initially prepared by thermal treatment of Kaolinite at 800 °C for 2 h. Sodium silicate solution (waterglass) was prepared by mixing sodium hydroxide, fumed silica and de-ionized water until a clear and viscous solution was formed. A geopolymer paste (Si/Al=1.77, Na2O/Al2O3=1.