05. The resulting clusters with an average tool picture preference (red) and an average animal picture preference (blue) for groups of 7- to 8-year-olds, 9- to 10-year-olds and adults are displayed on the standard Freesurfer surface in Fig. Y-27632 nmr 2(top). Significant picture category-selective clusters of activation where located in approximately the same location as those previously reported in the adult-literature (see Appendix A, Table 2 for cluster statistics); At all ages, tool picture selective regions encompassed the bilateral medial fusiform gyrus (FFG), the bilateral middle temporal gyrus (MTG), a dorsal occipitoparietal cluster extending into the intraparietal sulcus encompassing

the anterior intraparietal sulcus (AIP), the dorsal premotor cortex (dPMC) and left inferior frontal gyrus (IFG). Animal picture selective regions were located in the primary occipital cortex, and – more extensively in adults – the right FFG, and the right LOC just posterior to the region with a tool preference in the MTG. In line with findings by ( Dekker et al., 2011) these activations where organised in a similar manner across all age groups. However, there were several areas where the amplitude of the category preference (tool pictures vs fixation – animal pictures vs fixation), varied linearly with age. These age-related changes involved both decreases and increases in the amplitude of

category selective responses, depending on cortical area and picture category. See Appendix A, Fig. 1 and Table 3, for descriptions of areas where the amplitude of cortical category selectivity click here varied with age. In the activation maps in Fig. 2, clusters

with a significant average category preference for printed words within each age group are depicted for tool words (yellow) and animal words (light green), and are indicated by arrows and labels (see Appendix A, Table 2 for cluster statistics). Considering that visual similarity and frequency of words were matched across category, it is not surprising that the differential neural responses to tool- and animal words are substantially smaller than those to tool- and animal pictures. Nevertheless, the group of adults showed a preference for tool 3-oxoacyl-(acyl-carrier-protein) reductase names in a cluster in the left IFG/left dorsolateral prefrontal cortex (DLPFC), anterior – but adjacent – to an area with a preference for tool pictures in the IFG. Adults also showed a preference for tool names in the left LOC/MTG, in a region that partially overlapped with cortex with a preference for tool pictures. The group of 9- and 10-year-olds showed a preference for animal names in the left occipital pole, in a cluster that partially overlapped with a cortical area with a preference for animal pictures, but also with one with a preference for tool pictures. No regions with a category preference survived the statistical threshold in the group of 7- and 8-year-olds.