Our patient was treated in Bonn. His factor-VIII level was 1% and his inhibitor level was 0.5 Bethesda units/ml on admission. The dosages and inhibitor levels are shown in the figure. At first he received 3000 units of factor VIII and 2500 units of concentrated factor IX daily. His inhibitor level increased during the first week to about 1100 units/ml and did Selleckchem MK2206 not fall significantly until he had received 12 000 units of factor VIII per day for 10 days. The dose could then be reduced, and after 3 months with daily injections an inhibitor level of 1 unit/ml was obtained. The inhibitor concentration rose 3 weeks

later, the daily dosage of factor VIII having been reduced too far, but the inhibitor concentration fell again when the dose was increased. After 7 months he has no demonstrable inhibitor while on 3000 units of factor VIII and 1000 units of factor IX concentrate (‘Feiba’) daily. He received, due to shortage of feiba, other factor-IX concentrates in between. There have been a few bleeding episodes, mostly in one bad elbow but sometimes more general. In more general bleeds we often found a

positive ethanol test, increased amounts of fibrinogen-related Small molecule library antigens, shortened euglobulin-lysis time, a low platelet-count, and a defect in A.D.P., adrenaline, and collagen- induced platelet aggregation in vitro. He has biochemically no hepatic or renal damage. Platelet or leucocyte antibodies and hepatitis B antigen or antibody have not been found. He 上海皓元医药股份有限公司 has been able to do progressively more active physiotherapy, and is making great progress. Furthermore he has passed another examination, and is able to use his typewriter again. Except for the first days in Bonn he has administered the injections himself. A feature of this case is the very high level of inhibitor and the very large doses of factor VIII. “
“The severity of haemophilia A has traditionally

been classified by the dosage of factor VIII (FVIII) by one-step coagulation tests. However, an homogeneous group of patients with similar FVIII levels show clinical heterogeneity and 10–15% of the patients classified as severe haemophilia do not have a severe bleeding phenotype. Traditional tests used for measuring FVIII are not capable of detecting other prohaemorrhagic or prothrombotic factors. Global tests as the thrombin generation assay (TGA) may detect these haemostatic factors. So TGA may be an additional tool for classifying the actual severity of haemophilia. Our group is carrying out correlation tests between FVIII and TGA in platelet-poor and -rich plasmas (PPP and PRP, respectively). PRP has the inconvenience that must be done freshly soon after blood extraction. Our aim is to study the differences between TGA performed with fresh and frozen PRP and PPP and its implementation in multicenter studies. We included 70 patients with severe haemophilia A in prophylactic treatment.