08)d   Pipamperone 70 165 1.71 (1.29, 2.28) 1.54 (1.15, 2.06)   Haloperidol 75 106 2.87 (2.13, 3.86) 2.33 (1.72, 3.18)   Zuclopenthixol 38 56 2.78 Regorafenib research buy (1.83, 4.21) 2.44 (1.59, 3.75)   Thioridazine 7 17 1.59 (0.64, 3.93) 1.51 (0.60, 3.78)   Levomepromazine 8 27 1.01 (0.45, 2.28) 0.80 (0.35, 1.82)   Others 34 96 1.39 (0.93, 2.07) 1.19 (0.79, 1.78)  Atypical antipsychoticsc 11 44 0.95 (0.48, 1.86) 0.83 (0.42, 1.65)d   Risperidone 8 32 0.95 (0.43, 2.10) 0.84 (0.38, 1.88)   Quetiapine, olanzapine, clozapine 3 12 0.93 (0.26, 3.34) 0.83 (0.23, 3.02) aIf more than one antipsychotic had been dispensed before the index date, then all dispensings were taken into account. For

current, recent, and past users, the last antipsychotic was dispensed respectively within 30 days, between 31 and 182 days, and more than 182 days prior to the index date bAdjusted for confounders as presented in Table 3 cIn both the univariate as is the multivariate analysis also adjusted for other antipsychotics

dSignificant difference between conventional antipsychotics and atypical antipsychotics (p = 0.038 after Wald test). Table 5 presents the ORs for hip/femur fracture according to the pharmacological profile of the antipsychotic in current use. The use of antipsychotics with high prolactin-raising properties Selleckchem BI 10773 (i.e., most conventional antipsychotics and risperidone >4 mg/day) was associated with an PF299804 order increased risk of hip/femur fracture (ORadj 1.75 [95% CI 1.48, 2.08]), whereas antipsychotics with low prolactin-raising properties (i.e., most atypical antipsychotics including risperidone ≤4 mg/day) were not associated with an increased risk of fracture (ORadj 0.91 [95% CI 0.45, 1.85)]. After comparison of both groups, no significant difference was observed. Analysis stratifying current use according to the EPS properties of the antipsychotics suggested a trend towards increased risk with increasing EPS (ORadj 1.55 [95% CI 1.18, 2.04] for low EPS and ORadj 1.97 [95% CI 1.49, 2.61] for high EPS), but this trend did not reach statistical significance. Table 5 Risk of hip/femur fracture with current antipsychotic use according to the pharmacological properties Antipsychotic usea Cases Controls Univariate analysis Multivariate analysisb (n = 6,763) Fenbendazole (n = 26,341) OR (95% CI) OR (95% CI) No use 6,105 24,770 Referent Referent Past use 249 653 1.57 (1.35, 1.83) 1.33 (1.14, 1.56) Recent use 172 425 1.63 (1.36, 1.96) 1.38 (1.15, 1.66) Current use 237 493 2.00 (1.70, 2.35) 1.68 (1.43, 1.99)  Sedative properties           Low 89 144 2.54 (1.95, 3.31) 2.09 (1.59, 2.74)   Medium 53 125 1.78 (1.28, 2.47) 1.50 (1.07, 2.10)   High 95 224 1.75 (1.37, 2.24) 1.51 (1.17, 1.94)  EPS properties           Low 80 191 1.73 (1.33, 2.26) 1.55 (1.18, 2.04)   Medium 74 163 1.90 (1.44, 2.51) 1.58 (1.18, 2.10)   High 83 139 2.46 (1.87, 3.24) 1.97 (1.49, 2.