12–7.95 (m, 7H, Ar–H), 3.25 (s, 2H, CH2), 2.52 (s, 3H, CH3), 2.43

(s, 3H, CH3), 2.17 (s, 6H, 2CH3); 13C NMR (300 MHz, CDCl3) δ: 168.10, 148.97, 141.36, 138.28, 136.65, 135.22, 131.20, 129.21, 127.39, 125.70, 123.14, 116.56, 82.39, 41.97, 21.64, 20.95, 14.81; ESI C-MS, m/z calcd. for C19H21NS3 359.08 found [M+H]+ 360.5 BTZ-18 = 1H NMR (400 MHz, CDCl3) δ: 7.13–7.62 (m, 6H, Ar–H), 3.15 (s, selleck chemicals llc 2H, CH2), 2.37 (s, 3H, CH3), 2.20 (s, 6H, 2CH3); 13C NMR (300 MHz, CDCl3) δ: 158.28, 153.35, 149.17, 145.33, 135.29, 131.47, 125.06, 123.07, 113.79, 112.46, 82.22, 42.36, 20.81, 14.58; ESI-MS, m/z calcd. for C16H17NO2S3 335.50 found [M+H]+ 336.5. BTZ-17 = 1H NMR (400 MHz, CDCl3) δ: 7.20–9.42 (m, 6H, Ar–H), 3.52 (s, 2H, Selleck Alectinib CH2), 2.40 (s, 3H, CH3), 2.15 (s, 6H, 2CH3); 13C NMR (300 MHz, CDCl3) δ: 167.58, 150.91, 149.27, 145.31, 143.99, 142.49, 136.18, 135.19, 131.38, 125.68, 123.27, 83.90, 38.57, 20.88, 14.22; ESI-MS, m/z calcd. for C16H17N3S3 347.52 found [M+H]+ 348.2. BTZ-16 = 1H NMR (400 MHz, CDCl3) δ: 7.08–9.32 (m, 6H, Ar–H), 3.87 (s, 3H, OCH3), 3.54 (s, 2H, CH2), 2.16 (s, 6H, 2CH3); 13C NMR (400 MHz, CDCl3) δ: 166.92, 157.21, 150.91, 145.14, 145.09, 143.85, 142.43, 127.15, 124.77, 119.05, 116.60,

83.74, 55.01, 38.61, 14.21; ESI-MS, m/z calcd. for C16H17N3OS3 363.05 found [M+H]+ 364.05. All authors have none to declare. “
“The main focus of the ongoing researchers is to explore the natural remedies to cure innumerable diseases and disorders. Though the chemical drugs are the queen of pharmaceutical industries, they are causing several adverse effects. But the natural drugs or the bioactive compounds from terrestrial and marine plants are proven to be functionally active and it overcomes the disadvantage of the chemically derived drugs. 1 They hold within various secondary metabolites like antibiotics, mycotoxins, alkaloids, phenolic compounds, food-grade pigments and plant growth factors. Thus, they are the stealer of attraction of the researchers. Since last decade, marine seaweeds have been extensively used as traditional medication and dietary supplements of ancient Asia.2 and 3 Several

reports are available on the antibacterial, antiviral, anticoagulant and antitumour compound extraction Thiamine-diphosphate kinase from seaweeds.4, 5, 6 and 7 In the present study, methanolic extract of Sargassum tenerrimum was challenged for its antibacterial activity. The biological knowledge on S. tenerrimum is scanty as reviewed in the literatures. They are rich in variety of polysaccharides. Recent research implies that polysaccharides like inulin, oligofructose, galactooligosaccharides and lactulose can also act as potent prebiotic compounds against pathogenic microbes in animals and humans. 8 Similarly, fucoidan and guluronic acid-rich alginate derivative derived from S. tenerrimum has been proven to show its antiviral activity against the Herpes simplex viruses. 9 Unbelievably, extract from S.