“
“A 3-phosphonated N-confused ZD1839 Protein Tyrosine Kinase inhibitor phlorin 3 was synthesized by the reaction of N-confused porphyrin 1 and trimethyl or triethyl phosphite 2 in the presence of acetic acid in good yield. The presence of hydrogen and aryl substituents in one of the meso positions (CS)

generates a stereogenic center, resulting in configurationally stable enantiomers. The enantiomers were separated by HPLC and characterized by the circular dichroism method for the first time in the case of phlorin. Further oxidation of 3 by DDQ(2,3-dichloro-5,6-dicyano-1,4-benzoquinone) afforded the achiral 3-phosphonated N-confused porphyrin 4. Chiral dilorozinc 4-Zn and chlorocadmium 4-Cd, as well as achiral nickel(II) complexes 4-Ni were also characterized. For 4-Cd in the solid state, formation of a dimer consisting of heterochiral subunits joined by two H-bonds was established by a single crystal X-ray analysis. For 4-Cd, separation of enantiomers was achieved. Slow racemization of 4-Cd in solution prevented the absolute configuration determination

by the X-ray method indicating the labile character of the complex. The relationship between circular dichroism and absolute configuration of 3a and 4-Cd was established on the basis of TD-DFT calculations.”
“Background\n\nWhen a woman has had a previous caesarean birth, there are two options for her care in a subsequent DMH1 pregnancy: planned elective repeat caesarean or planned vaginal birth. While there are risks and benefits for both planned elective repeat caesarean birth and planned vaginal birth after caesarean (VBAC), current sources of information are limited to non-randomised cohort studies. Studies designed in this way have significant potential for bias and consequently conclusions based on these results are limited in their reliability

and should be interpreted with caution.\n\nObjectives\n\nTo assess, using this website the best available evidence, the benefits and harms of a policy of planned elective repeat caesarean section with a policy of planned VBAC for women with a previous caesarean birth.\n\nSearch methods\n\nWe searched the Cochrane Pregnancy and Childbirth Group’s Trials Register (30 September 2013) and reference lists of retrieved studies.\n\nSelection criteria\n\nRandomised controlled trials with reported data that compared outcomes in mothers and babies who planned a repeat elective caesarean section with outcomes in women who planned a vaginal birth, where a previous birth had been by caesarean.\n\nData collection and analysis\n\nTwo review authors independently assessed trial quality and extracted data.\n\nMain results\n\nTwo randomised trials involving 320 women and their infants were included. However, data for maternal and infant clinical outcomes were available from one trial with very low event rates, involving 22 women only.