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41. CBO (2011) Guideline for osteoporosis and fracture prevention, third revision. [Richtlijn Osteoporose en fractuurpreventie, derde herziening]. http://www.cbo.nl/Downloads/1385/OsteoporoseRichtlijn%202011.pdf. Accessed 12 Jan 2012 42. Van Staa TP, Laan RF, Barton IP, Cohen S, Reid DM, Cooper C (2003) Bone density threshold and other predictors of vertebral fracture in patients receiving oral glucocorticoid therapy. Arthritis Rheum 48(11):3224–3229PubMedCrossRef 43. Imaz I, Zegarra P, Gonzalez-Enriquez J, Rubio B, Alcazar R, Amate JM (2010) Poor bisphosphonate adherence for treatment of osteoporosis CA4P in vitro increases fracture risk: systematic review and meta-analysis. Osteoporos Int 21(11):1943–1951PubMedCrossRef”
“Dear Editor, According to Wiklund et al. (1), mothers who breastfed Temsirolimus in vivo for more than 33 months had greater bone strength than mothers who breastfed for less than 12 months (p < 0.05). These findings are in agreement with our results from a study of 1633 post-menopausal Hispanic women from Barranquilla, Colombia, where we did not find any long-term adverse effect of prolonged lactation (up to 48 months) on women’s bone health (2). In another
study we found an increase in the bone mineral density and in the total bone and calcium content in all CHIR-99021 cost skeletal areas after each delivery and a reduced risk of bone fractures (OR 0.41; 95 % CI 0.28̶0.61; p < 0.00002) in women with two or more deliveries compared with nulliparous women (3). This “gestational bone mass peak” is analogous to the bone mass peak observed during puberty. One important question that remains to be answered
by 3-mercaptopyruvate sulfurtransferase the study by Wiklund et al. is whether greater maternal bone size and bone strength are also associated with a reduced risk of bone fractures in the long run. References 1. Wiklund PK, Xu L, Wang Q, Mikkola T et al (2012) Lactation is associated with greater maternal bone size and bone strength later in life. Osteoporos Int 23:1939–1945. doi:10.1007/s00198-011-1790-z PubMedCrossRef 2. Cure-Cure C, Cure-Ramirez P, Lopez-Jaramillo P (1998) Osteoporosis, pregnancy and lactation. Lancet 352(9135):1227–1228CrossRef 3. Cure-Cure C, Cure-Ramirez P, Teran E, Lopez-Jaramillo P (2002) Bone-mass peak in multiparity and reduced risk of bone fractures in menopause. Int J Gynaecol Obstet 76(3):285–291PubMedCrossRef”
“Dear Editor, We thank the authors of the letter [1] for their interest in our publication and their detailed work-up of its content. We appreciate the comments and wish to briefly address the main questions raised.