Application of the ethylene inhibitor, 1-methylcyclopropene, decreased mesocarp Crenigacestat browning, embryo development, seedling growth, and ion leakage, and down-regulated polyphenol oxidase activity. The results demonstrate that ethylene-mediated embryo growth in whole fruit is involved in the mesocarp response to ethylene perception and the development
of CI disorders.”
“Background: When a rectal cancer is located at less than 4 cm from the anal verge, abdominoperineal resection (APR) is generally performed. If an ideal surgery that could replace APR were to be developed, it could contribute to anal preservation in patients with very low rectal cancer. The aim of this study was to investigate oncologically whether intersphincteric resection (ISR) could replace APR for a very low rectal cancer.
Methods: Between 2001 and 2011, ISR was curatively performed in 124 patients with a very low rectal cancer who might otherwise have been treated with APR. No patient received preoperative chemoradiotherapy. The median
duration of follow-up was 65 months (range 14-122 months). Local recurrence was defined as only intra-pelvic recurrences including lateral lymph node metastasis. The survival rate was calculated using the Kaplan-Meier click here method.
Results: Postoperative morbidity including anastomotic leakage (5.6%) was 12%. There was no in-hospital mortality. In those patients with Stages I, II, and III disease, the local recurrence rate was 4.7%, 4.9%, and 5.0%, respectively. The recurrence-free
5-year survival rates were 92.2% (95% CI: 84-100%), 81.9% (95% CI: 70-94%) and 69.6% (95% CI: 53-87%) at each stage, respectively. The cancer-specific 5-year survival rates were 90.5% (95% CI: 81-100%), 91.0% (95% CI: CT99021 clinical trial 82-100%), and 83.6% (95% CI: 70-97%) at each stage, respectively. The overall recurrence-free survival and local recurrence rates after ISR were similar to those after APR.
Conclusions: The ISR procedure appears to be oncologically acceptable, replacing APR in selected patients. Accumulated experience supports this practice worldwide in future. (C) 2013 Elsevier Ltd. All rights reserved.”
“Paramyotonia congenita in 22 members of Arab (Omani) family is reported. Four generations were affected. All had early onset around 1 year of age, with myotonia and cold intolerance. Age of onset in the index case was at 3 months of age. Six members with the disease were examined and investigated. To our knowledge, this is the first report of the condition from this region. Childhood presentation and differential diagnosis is discussed.”
“Status epilepticus treatment involves the use of several pharmacologic compounds, which are conceptually divided into three successive and additional lines of action.