Comparison with experiments shows that the time scale of BCR oligomer formation predicted by our model (less than 10 s) is well within the time scale of experimentally observed association of BCR with Src-family kinases (10-20 s). (C) 2012 Elsevier Ltd. All rights reserved.”
“The relationship between theory of mind (ToM) and autobiographical memory (AM) in high-functioning autism (HFA) and Asperger syndrome (AS) has never been investigated. Here, we show that ToM abilities could be predicted by levels of AM in HFA and AS as
compared to controls, suggesting that difficulties in AM are closely related to ToM impairments in HFA and selleck products AS. (C) 2009 Elsevier Ireland Ltd. All rights reserved.”
“A mathematical model of the within-vector dynamics of Plasmodium falciparum in an Anopheles mosquito with unbiased random mating and incomplete fertilization is used to investigate
the effects of varying fecundity and population size on the gametocyte sex ratio when strains maximize their individual fitnesses. Previous studies considered either the effects of variable fecundity or the effects of incomplete fertilization. Here we investigate the simultaneous effects of variable Selleckchem GSK2879552 fecundity, incomplete fertilization, and variable number of ingested gametocytes per strain on the optimal gametocyte sex ratio. Our model results agree with others in the case of two identically sized populations in that large differences in fecundities lead to female-biased total population sex ratios. When the assumption of identically sized populations is relaxed in our model, population sex ratios vary from highly female-biased to slightly male-biased, Phospholipase D1 depending on relative strain fecundities and population sizes. Our results provide a plausible explanation for the high variation in gametocyte sex ratios of P. falciparum observed in nature. (C) 2012 Elsevier Ltd. All rights reserved.”
“Associations between suicide, violent behaviour and both hypocholesterolaemia and low 5-hydroxyindolacetic
acid (5-HIAA) in the cerebrospinal fluid (CSF) have been suggested. The relationships between lipids, the serotonergic system, suicidal and aggressive behaviors are complex. We explored relationships between serum cholesterol, CSF 5-HIAA. the planning subscale of suicide intent and violence of attempted suicide method in 13 medication-free male suicide attempters and eight healthy volunteers. Serum high-density lipoprotein cholesterol (HDL-C) levels were significantly lower in suicide attempters than in controls. HDL-C showed a significant positive correlation with the planning subscale of suicide intent in non-violent suicide attempters. A positive association was observed between CSF 5-HIAA and serum cholesterol in suicides.