Furthermore, given that anthocyanins also have been described to active the nrf-2 transcription factor [20, 48, 49] and induce heat shock proteins [52] it is feasible that blueberry-derived anthocyanins may activate similar and/or parallel adaptive mechanisms within damaged muscle and underlie the findings observed here AZD6738 molecular weight and by others. It is also unclear whether particular anthocyanins or other phytochemicals from fruits (or other sources) are responsible for or synergistic to the benefits reported here. Studies using isolated polyphenolics indicate that they potentially possess diverse

functional efficacy within the body, which may not necessarily complement each other. It is feasible that certain fruit species or even certain cultivars (or combinations thereof) may provide the combination of polyphenolics that synergistically act together to most optimally deliver a specific biological action or actions that complement the adaptive events desired

by exercise training athletes. Conclusions In conclusion, our study provides evidence that ingestion of a New Zealand blueberry Berzosertib beverage prior to and after eccentric muscle damage accelerates recovery of muscle peak isometric strength, independent of the beverages inherent antioxidant properties. Standardizing blueberry fruit intake based on the lean body mass (g/kg), (10058-F4 mouse assuming that the greater the muscle mass, the greater the force produced during the maximal eccentric protocol [53]) may have given more accurate results. This study has practical implications for all who turn to exercise and dietary antioxidant-rich supplements to maintain their health and performance. It is especially of potential relevance to all athletes who compete over successive days as well as to the general sporting community. Although the literature is divided as to the benefits

Urease of antioxidant supplements in affecting the initial muscle damage/inflammation and subsequent recovery of muscle function, this study supports the idea that blueberry consumption induces cellular adaptive events that serve to accelerate muscle repair and recovery of muscle isometric strength. Identifying specific dietary interventions that complement exercise-induced short-term as well as adaptive responses following various exercise strategies (i.e. aerobic exercise-induced oxidative stress or EIMD) may be of greater importance in maintaining health and athletic performance than the consumption of generic dietary supplements based upon their apparent high antioxidant capacity. Follow up studies are therefore warranted with blueberry as a food to assist exercise and should focus upon dose and timing to ascertain important optimum parameters.