However, the reduction of MAP that was induced by swimming, but not by running, was associated with an increase in ANP, a hormone with a well-known

www.selleckchem.com/products/SP600125.html role as an anti-hypertensive agent, indicating that different mechanisms could be involved in the same response depending on the type of physical training. The authors thank CNPq, FAPES and FACITEC for providing financial support. “
“The Publisher regrets that during the production of the above paper, errors were introduced into Table 1. We apologize to the authors and readers for any inconvenience caused as a result of this error. The corrected Table 1 is reproduced below. “
“B-type natriuretic peptide (BNP), a 32-amino-acid peptide member of the natriuretic peptide (NP) family, is released by ventricular cardiomyocytes under high pressure and volume overload states.

Vasodilation, diuresis, natriuresis, and inhibition of the activities of the renin–angiotensin–aldosterone and the sympathetic nervous systems are among its hemodynamic actions. In clinical practice, BNP plasmatic measurement is used both as a diagnostic tool for exclusion of heart failure [22] and as a predictor of coronary heart disease, stroke, and other cardiovascular outcomes [11]. An additional but less well-studied function of BNP is its action as a promoter of lipolysis in the adipose tissue, which has generated speculation regarding its involvement in the biological mechanisms of obesity and cardiac cachexia [4], selleck inhibitor [15] and [33]. Population-based studies performed in North America, Europe and Asia have shown that body mass index (BMI) is inversely related to BNP levels, and, consequently, obese individuals have lower

BNP levels than lean ones, even in the presence of heart failure [8], [9], [21] and [38]. Few studies have addressed the influence of other measures of adiposity on BNP levels that may be important in the application of the peptide as a diagnostic or prognostic tool [9] and [34]. Cardiomyopathy is the main feature of Chagas disease [6], a disorder caused by the protozoan Trypanosoma cruzi, endemic in South America and Central America. It is characterized by heart block, ventricular arrhythmia, and heart failure with left ventricular systolic OSBPL9 and/or diastolic dysfunction. Left ventricular systolic and diastolic dysfunctions are associated with higher BNP levels [2] and [30]. Recently, a large community-based study showed that there was a graded and strong cross-sectional relationship between BNP levels and T. cruzi infection in old age and that BNP is an independent predictor for the 10-year mortality rate in infected elderly [17]. In addition, adipose tissue has been described as an important target organ for T. cruzi infection [25]. To our knowledge, the effect of T. cruzi infection on the relationship between BNP and BMI or other anthropometric measures is unknown.