In addition, multiple linear find more regression analysis is used for the analysis of combined action of different parameters on PTA3,4,6 values. Modelling

proceeded in several steps. First, bivariate relationships of the covariates with PTA3,4,6 are checked by simple linear regression. All analyses are adjusted for age by including age as a covariate. Most of the categorical variables are dichotomous, and others are converted into dummy variables before MCC950 nmr inclusion into the analysis. Variables are retained for further modelling if the age-adjusted p value of the individual testing was <0.10. Second, a multiple linear regression model is created using the selected set of potential predictive variables. Relevant variables are selected using a backward stepwise elimination procedure,

with p < 0.05 for inclusion and p < 0.10 for exclusion. The use of hearing protection devices reduces noise exposure, which may lead to overestimation of exposure levels and attenuation of the exposure–response relationship (Sbihi et al. 2010). To reduce the effects of hearing protection, some analyses are adjusted for reported HPD use by performing stratified analyses for the subgroups of HPD users and non-users. The level for statistical significance is taken as p < 0.01 for all analyses. Results General population characteristics The total population of 27,644 men is divided into a large group of noise-exposed employees (n = 24,670) Anlotinib supplier and an internal non-exposed control group (n = 1,016).

The exposed group is slightly older than that of the control group (average age 44.3 and 40.9 years, respectively, see Table 2). Noise-exposed workers are significantly longer employed in both the construction industry and their current occupation than CYTH4 controls. Mean employment differences are 12.4 and 6.7 years, respectively. More than half of the exposed workers have always been employed in the current job (55.5%). Of the exposed employees, 75.5% claim to use hearing protection, 22.1% have complaints of worsened hearing and 39.1% are bothered by noise during work. Smoking status, alcohol intake and blood pressure do not differ between the groups. Table 2 Demographics and hearing loss risk factors, by subject group Variables Exposed Controls n 24,670 1,016 Age, yrs (mean ± SD)* 44.3 ± 11.4 40.9 ± 11.5 Years in construction (mean ± SD)* 24.3 ± 12.6 11.9 ± 10.2 Years in current job (mean ± SD)* 18.6 ± 12.8 11.9 ± 10.2 Always employed in current job (%)* 55.5 – Usage of HPD (%)* 75.3 9.9 Complaints of worsened hearing (%)* 22.1 11.7 Bothered by noise during work (%)* 39.1 4.5 Smoking      Never (%) 35.0 36.4  Current (%) 32.8 33.5  Ex (%) 32.2 30.1 Cigarettes/day (mean ± SD) 14.7 ± 9.9 14.2 ± 9.2 Years of smoking (mean ± SD) 18.9 ± 11.8 18.9 ± 11.7 Alcohol intake, glasses/week (mean ± SD) 9.8 ± 10.3 9.8 ± 10.3 Hypertension (%) 21.6 19.7 LAeq, 8h (dBA)      80–84 (%) 0.6 –  85–89 (%) 29.0 –  90–94 (%) 68.7 –  >95 (%) 1.