In order to obtain more recent and robust data, we updated EGFR inhibitor these hip fracture rates using 2006 hospital discharge data for non-Hispanic white women and men from the Healthcare Cost and Utilization Project (HCUP) Nationwide Inpatient Sample (NIS) that was previously used by Burge et al. [4] to estimate national hip fracture incidence rates for the white population in 2001. The NIS is a random sampling of 20% of hospital discharges each year. This data set is created by the Agency for Health Care Research and Quality through HCUP and calculates weightings that allow discharge rates to be up-weighted to project rates for

the entire US population. The most recent data available to us were for 2006 and include reporting from 38 states. As in previous analyses [4], proximal femur fractures were defined as ICD-9-CM codes 820.0× (transcervical), 820.2× (pertrochanteric), and 820.8× (neck of femur).

To be conservative, open fractures were excluded. Moreover, only cases with a primary diagnosis of fracture were included: Any patients with only secondary fracture diagnoses were excluded, as were hospital admissions due to severe trauma (based GSK2126458 clinical trial on E-codes; less than 2% of the total). Although ten states reported little or no information on race, 24 of the 38 states in 2006 NIS had acceptable or near-complete race reporting, with 0–8% of hip fracture subjects missing race (most 1–2%); four other states had 16–42% missing race data. Based on race reporting from these 28 states, we derived an equation that predicted the percentage of each state’s hip fractures that occurred among whites from the percentage of the white population in that state. The contribution of each state to the equation was weighted by its number of hip fractures. Next, we applied the weighted equation to all hip fractures missing race (about one

quarter of the total). We then obtained US Census projections for 2006 and Olopatadine collected denominator numbers of non-Hispanic whites by sex and age; hip fracture incidence rates for this population were then estimated by OSI-906 mouse 5-year age groups. All programming was done using the NIS-specific macros and the SAS programming language (SAS 9.1, SAS Institute, Cary, NC). A smoothing function from Proc REGLIN in SAS was then applied to the 5-year incidence rates to smooth the data and create single-year of age incidence rates to be used in the US-FRAX algorithm. The resulting hip fracture incidence rates are shown in Table 1 and in Fig. 1a and b for men and women, respectively. Although overall age- and sex-adjusted rates were similar between Olmsted County in 1989–1991 and NIS in 2006, only 19 hip fracture cases were available to estimate the Olmsted County rates for women age 50–64 years, and only nine cases for men in this age group.