of patients Mean change (g/cm2) Mean relative change from baseline (%) Lumbar spine L2-L4  Baseline to year 10 155 0.253 ± 0.151*** 34.5 ± 20.2***  Years 0–5 223 0.179 ± 0.105*** 23.9 ± 13.9***  Years 6-10 146 0.070 ± 0.115** 7.9 ± 12.6** Femoral neck  Baseline to year 10 147 0.060 ± 0.066*** 10.7 ± 12.1***  Years 0–5 225 0.050 ± 0.044*** 8.8 ± 8.0***  Years 6–10 130 0.010 ± 0.056* 1.8 ± 9.1* Total hip  Baseline to year 10 147 0.077 ± 0.084*** 11.7 ± 13.6***  Years 0–5 225 GW786034 0.080 ± 0.056*** 12.1 ± 11.2***  Years 6–10 130 0.000 ± 0.067 0.04 ± 8.9 *P < 0.05; **P < 0.01; ***P < 0.001, for within-group comparison Correlation between changes

in BMD and incidence of fracture Our analysis included 116 women with femoral neck and total hip BMD and fracture data available over the 10 years of follow-up. During the last 2 years of follow-up, 12 of these patients experienced a new vertebral fracture. After having controlled for age, body mass index at year 9, BMD at year 9, number

of vertebral fractures at year 0, and number of new vertebral fractures from years 0 to 8, we found that the change in femoral neck BMD from years 9 to 10 was significantly associated with vertebral fractures incidence during the same period of time (P = 0.03). Each 1% increase in femoral neck BMD was associated with a 15% (95% adjusted confidence interval [CI] 2–26%) decrease buy CCI-779 in risk for new vertebral fracture. The same trend was observed for total hip BMD (7%; 95% CI 3–17%), but did not reach statistical significance (P = 0.16). Women with new vertebral fractures from years 9 to 10 experienced a simultaneous decrease of 2.4 ± 4.7% in femoral neck BMD, compared with an increase of 1.5 ± 8.3% in women without new vertebral

fracture. Safety During the extension Vasopressin Receptor study, 226 patients (95%) in the 10-year population reported at least one emergent adverse event on treatment. The comparison of the incidences of the most frequent adverse events observed with strontium ranelate in the 5 years of the SOTI and TROPOS studies and those in years 6 to 10 (Table 4) shows no increase after long-term use in an aging population. The annual incidence of events related to venous thromboembolism in patients Erastin molecular weight treated with strontium ranelate during the 5 years of the extension study (i.e. patients who had received treatment for 10 years) was 0.4%. The neurological disorders reported included memory losses (annual incidence 1.1%) and disturbances in consciousness (annual incidence 0.8%), but no case of seizure. Moreover, no new signal was detected over the last 2 years of the extension study; no cases of drug-related hypersensitivity reactions were reported in the extension study.