Polymeric nanoparticles are featured prominently in a wide variety of applications such as toners, coatings, adhesives, instrument

calibration standards, column packing materials for chromatography, biomedicine, and biochemical analysis [5–7]. An emerging application focuses on metal-coated conductive polymeric particles for anisotropic conductive adhesives used in liquid crystal displays and microsystems. The use of these particles could reduce package sizes Ibrutinib in vivo and manufacturing costs and entirely eliminate the use of lead in these systems [8–11]. The continued expansion of polymeric nanoparticles to new applications has revealed unexpected behaviors and potential shortcomings. Therefore, a complete understanding of their properties is of great importance for their successful use. Most of the previous research on nanoscale polymers have been focused on properties R428 mouse of thin polymer films due to their relatively easy preparation, characterization, and established applications. It has been explicitly shown that the glass transition temperature (T g) of polymer thin films is reduced from that of the bulk due

to the presence of a free interface, and T g is found to be strongly dependent on the film thickness and chain architecture [12–15]. Several studies have been conducted on the thermal properties of polymeric particles and reached similar conclusions as with thin films [16–18]. However, few studies have been performed on the mechanical characterization of freestanding polymeric nanoparticles

because of their small size and spherical geometry. Recently, a nanoindentation-based flat-punch experimental technique was developed to characterize the mechanical properties of isolated micron-sized polymeric particles [19, 20]. The mechanical response Cell press was shown to be highly dependent on the particle size and cross-link density [21, 22]. A limited number of computational studies have been carried out to investigate structure and properties of polymeric nanoparticles at the molecular level. Fukui et al. [23] developed a method based on molecular dynamics (MD) to generate polymeric nanoparticle models with linear chain architectures in a layer-by-layer manner. Their results indicated that structural and thermal properties are dependent on particle size. Hathorn et al. [24] investigated the dynamic collision of polyethylene (PE) nanoparticles containing linear molecular architectures. Very recently, our group has studied the effect of size on the mechanical properties of PE nanoparticles via coarse-grained MD simulation (Zhao JH, Nagao S, Odegard GM, Zhang ZL, Kristiansen H, He JY: Size-dependent mechanical behavior of nanoscale polymer particles through coarse-grained molecular dynamics simulation. submitted).