Shariat SF, Ashfaq R, Roehrborn CG, Slawin KM,

Lotan Y: Expression of survivin and apoptotic biomarkers in benign prostatic hyperplasia. J Urol 2005, selleck 174: 2046–2050.PubMedCrossRef 34. Hinnis AR, Luckett JC, Walker RA: Survivin is an independent predictor of short-term survival in poor prognostic breast cancer patients. Br J Cancer 2007, 96: 639–645.PubMedCrossRef 35. Ogris M, Walker G, Blessing T, Kircheis R, Wolschek M, Wagner E: Tumor-targeted gene therapy: strategies for the preparation of ligand-polyethylene glycol-polyethylenimine/DNA complexes. J Control Release 2003, 91: 173–181.PubMedCrossRef 36. Hosseinkhani H, Kushibiki T, Matsumoto K, Nakamura T, Tabata Y: Enhanced suppression of tumor growth using a combination of NK4 plasmid DNA-PEG engrafted cationized dextran complex and ultrasound irradiation. Cancer Gene Ther 2006, 13: 479–489.PubMedCrossRef 37. Haag P, Frauscher F, Gradl J, Seitz A, Schäfer G, Lindner JR, Klibanov AL, Bartsch G, Klocker H, Eder IE: Microbubble-enhanced ultrasound Fulvestrant mw to delivery an antisense oligodeoxynucleotide targeting the human androgen receptor into prostate tumours. J Steroid Biochem Mol Biol 2006, 102: 103–113.PubMedCrossRef 38. Dittmar KM, Xie J, Hunter F, Trimble C, Bur M, Frenkel V, Li KC: Pulsed high-intensity focused ultrasound enhances systemic administration of naked DNA in squamous cell carcinoma model: Initial Experience. Radiology 2005, 235: 541–546.PubMedCrossRef

39. Howard CM, Forsberg F, Minimo C, Liu JB, Merton DA, Claudio PP: Ultrasound guided site specific gene delivery system using adenoviral vectors and commercial ultrasound contrast agents. J Cell Physiol 2006, 209: 413–421.PubMedCrossRef 40. Yanagisawa K, Moriyasu F, Miyahara T, Yuki M, Iijima H: Phagocytosis of ultrasound contrast agent microbubbles by Kupffer cells. Ultrasound Med Biol 2007, 33: 318–325.PubMedCrossRef 41. Gao Z, Fain Aprepitant HD, Rapoport N: Ultrasound-enhanced tumor targeting of polymeric

micellar drug carriers. Mol Pharm 2004, 1: 317–330.PubMedCrossRef 42. Bekeredjian R, Kroll RD, Fein E, Tinkov S, Coester C, Winter G, Katus HA, Kulaksiz H: Ultrasound targeted microbubble destruction increases capillary permeability in hepatomas. Ultrasound Med Biol 2007, 33: 1592–1598.PubMedCrossRef 43. Lakhani SA, Masud A, Kuida K, Porter GA Jr, Booth CJ, Mehal WZ, Inayat I, Flavell RA: Caspases 3 and 7: key mediators of mitochondrial events of apoptosis. Science 2006, 311: 847–851.PubMedCrossRef 44. Chipuk JE, Kuwana T, Bouchier-Hayes L, Droin NM, Newmeyer DD, Schuler M, Green DR: Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis. Science 2004, 303: 1010–1014.PubMedCrossRef 45. Chen YC, Shen SC, Lee WR, Hsu FL, Lin HY, Ko CH, Tseng SW: Emodin induces apoptosis in human promyeloleukemic HL-60 cells accompanied by activation of caspase-3 cascade but independent of reactive oxygen species production. Biochem Pharmacol 2002, 64: 1713–1724.