Table 4 Incidence of fractures (yes/no), unadjusted and adjusted odds ratios according to the independent variables Variable   Unadjusted analysis Adjusted analysis Lifetime incidence of fractures (95%CI) Odds ratio (95%CI) P value Odds ratio (95%CI) P value Sex     <0.001a   <0.001a Boys 17.0% GSK1904529A research buy (15.4; 18.5) 1.00   1.00   Girls 11.6% (10.2; 12.9) 0.64 (0.54; 0.76)   0.64 (0.54; 0.76)   Family income at birth (minimum wages)     0.17b   0.18b ≤1 14.6% (12.2; 17.1) 0.94 (0.65; 1.35)   0.94 (0.65; 1.36)   1.1–3.0 13.1% (11.5; 14.5) 0.82 (0.59; 1.15)   0.82 (0.59; 1.15)   3.1–6.0 14.5% (12.3; 16.6) 0.93 (0.65; 1.32)   0.93 (0.66; 1.33)   6.1–10.0 17.9%

(13.7; 21.8) 1.19 (0.79; 1.80)   1.17 (0.77; 1.78)   >10.0 15.4% (11.4; 19.5) 1.00   1.00   Maternal schooling at birth (years)     0.92b   0.41b 0 15.2% (8.0; MCC-950 22.3)

1.00   1.00   1–4 14.4% (12.3; 16.5) 0.94 (0.53; 1.67)   0.92 (0.52; 1.63)   5–8 13.8% (12.3; 15.3) 0.90 (0.51; 1.58)   0.84 (0.48; 1.48)   ≥9 14.6% (12.5; 16.7) 0.95 (0.54; 1.70)   0.84 (0.47; 1.52)   Pre-pregnancy body mass index     0.10b   0.71b <20.0 kg/m2 15.7% (13.4; 17.9) 1.00   1.00   20.0–24.9 kg/m2 13.4% (12.0; 14.8) 0.84 (0.68; 1.03)   0.83 (0.67; 1.02)   25.0–29.9 kg/m2 13.3% (10.9; 15.7) 0.83 (0.63; 1.08)   0.81 (0.62; 1.07)   ≥30 kg/m2 18.2% (13.0; 23.3) 1.20 (0.82; 1.76)   1.15 (0.78; 1.70)   Maternal smoking during pregnancy     0.25a   0.17a No 13.8% (12.5; 15.0) 1.00   1.00   Yes 15.1% (13.2; 16.9) 1.11 (0.93; 1.33)   1.13 (0.95; 1.36)   Maternal age at delivery (years)     0.02b   0.008b

<20 11.8% (9.5; 14.1) 1.00   1.00   20–34 14.3% (13.0; 15.5) 1.24 (0.97; 1.58)   1.23 (0.96; 1.57)   ≥35 17.5% (14.1; 20.8) 1.58 (1.15; 2.17)   1.55 (1.12; 2.15)   Gestational age (weeks)     0.25b   0.24b <37 12.5% (9.0; 16.0) 1.00   1.00   37–38.9 13.7% (12.3; 15.1) 1.12 (0.79; 1.57)   1.04 (0.72; 1.21)   ≥39 15.2% (13.5; 16.8) 1.26 (0.89; 1.78)   1.16 (0.79; 1.68)   Birth weight (g)     0.08b   0.12b <2,500 10.8% (7.8; mafosfamide 13.9) 1.00   1.00   2,500–3,499 14.1% (12.8; 15.4) 1.35 (0.97; 1.89)   1.35 (0.97; 1.89)   ≥3,500 15.4% (13.3; 17.4) 1.49 (1.05; 2.13)   1.42 (0.99; 2.03)   Birth length (cm)     0.002b   0.03b ≤46 9.9% (7.4; 12.3) 1.00   1.00   46.1–48.0 14.0% (12.0; 16.0) 1.49 (1.07; 2.06)   1.56 (1.11; 2.21)   48.1–50.0 14.9% (13.2; 16.6) 1.61 (1.18; 2.19)   1.70 (1.18; 2.45)   >50.0 15.8% (13.5; 18.1) 1.72 (1.24; 2.38)   1.80 (1.16; 2.80)   aLikelihood ratio test for heterogeneity bLikelihood ratio test for linear trend The multivariable analysis was repeated (Table 5) using the number of fractures (0, 1, 2, 3) as the outcome variable in a Poisson Rabusertib regression model. Risk factors were consistent with those presented in the logistic regression using a dichotomous variable (yes/no). Table 5 Poisson regression using number of fractures as the outcome variable Variable Prevalence ratio (95%CI) P value Sex   <0.001a Boys 1.00   Girls 0.73 (0.63; 0.84)   Family income at birth (minimum wages)   0.04b ≤1 0.80 (0.