The goal of this Symposium was to present current diagnostic pathology or nomenclature issues to the toxicologic pathology community. This article presents summaries of the speakers’ presentations, including diagnostic or nomenclature issues that were presented, select images that were used for audience voting or discussion, and the voting results. Some lesions and topics covered during the symposium include: treatment-related atypical hepatocellular foci of cellular alteration in B6C3F1 mice; purulent ventriculoencephalitis in a young BALB/c Sirtuin inhibitor mouse; a subcutaneous malignant schwannoma in a RccHan:WIST rat; spontaneous nasal septum hyalinosis/eosinophilic
substance in B6C3F1 mice; a rare pancreatic ductal cell adenoma selleck compound in a young Lewis rat; eosinophilic crystalline pneumonia in a transgenic mouse model; hyaline glomerulopathy in two female ddY mice; treatment-related intrahepatic erythrocytes in B6C3F1 mice; treatment-related subendothelial hepatocytes in B6C3F1 mice; spontaneous thyroid follicular cell vacuolar degeneration in a cynomolgus monkey; congenital hepatic fibrosis in a 1-year-old cat; a spontaneous adenocarcinoma of the middle ear
in a young Crl:CD(SD) rat; and finally a series of cases illustrating some differences between cholangiofibrosis and cholangiocarcinoma in Sprague Dawley and F344 rats.”
“Objective. To assess whether serum magnesium concentration can predict risk of short-term outcome of acute ischemic stroke. Methods.
Between January 1, 2006 and December 31, 2008, 1493 patients with acute ischemic stroke were recruited from four hospitals in Shandong province, P. R China. Data on demographic characteristics, life style risk factors, history of cardiovascular disease, admission blood pressure and other clinical characteristics were collected from all subjects. The short-term outcome was defined as neurological deficiency NIHSS >= 10 or death (NIHSS >= 10/death). The Cox proportion hazard regression model was used to evaluate the association between serum magnesium concentration and risk of short-term outcome of acute ischemic stroke. Results. this website Serum magnesium concentration in subjects with NIHSS >= 10/death was lower than those with NIHSS < 10 (p < 0.05). When comparing the highest quartile of serum magnesium concentration with the lowest quartile in an unadjusted model, there was a decreased risk of NIHSS >= 10/death in individuals with the highest quartile; the risk ratio (RR) was 0.47 (p < 0.05). However, after adjustment for age, sex, serum calcium concentration, serum potassium concentration and other covariates, the fourth and the third quartiles of serum magnesium concentration were associated with decreased risks of NIHSS >= 10/death; the RRs were 0.40 and 0.56 (all p < 0.05), respectively.