After we controlled for level differences, a differential pattern

of individual differences in change appeared for the three dimensions: Age contributed to a greater decline in aging satisfaction but an increase in the discrepancy of felt age. A higher number or illnesses at baseline attenuated change in felt age discrepancy. Future research on change of self-perceptions or aging will provide insight into mechanisms of resilience of the aging self in later life.”
“Parkinson’s disease is a neurodegenerative disorder characterized by progressive degeneration of dopaminergic neurons in the substantia nigra. Accumulating evidence has Suggested that inflammation in the brain participates in the pathogenesis of Parkinson’s disease. Luteolin, a polyphenolic compound found in foods of

plant origin. belongs to the flavone subclass of flavonoids, buy BAY 11-7082 and has been shown to possess antimutagenic, antitumorigenic, antioxidant and antiinflammatory properties. In this study, we found that luteolin concentration-dependently attenuated selleck products the lipopolysaccharide (LPS)-induced decrease in [(3)H]dopamine uptake and loss of tyrosine hydroxylase-immunoreactive neurons in primary mesencephalic neuron-glia cultures. Moreover, luteolin also significantly inhibited LPS-induced activation of microglia and excessive production of tumor necrosis factor-alpha, nitric oxide and superoxide in mesencephalic neuron-glia cultures and microglia-enriched cultures. Our results demonstrate that luteolin may protect dopaminergic neurons from LPS-induced injury and its efficiency in inhibiting microglia

activation may underlie the mechanism. (C) 2008 Elsevier Ireland Ltd. All rights reserved.”
“We investigated associations between personality and health cognitions and behaviors related to preparation for future care among 355 Selleckchem Gemcitabine primary care patients who were 65 years of age and older. Path analyses examined the effects of the personality traits of neuroticism, extraversion, (openness to experience, agreeableness, and conscientiousness on health cognitions about future care (avoidance, awareness), health-planning behaviors (gathering information, decision making, and planning), and belief’s about planning, while covarying age, gender, education, medical burden, functional status, and depression-symptom severity. Higher levels of neuroticism. openness, and agreeableness were associated with greater awareness of care needs; higher openness was also associated with more gathering of information and less avoidance. Extraversion and conscientiousness were not related to future-oriented health cognitions. Depression was inversely associated with the gathering of information. Age and education were related to more positive beliefs about the planning.