1% Eu(3+) doped glass ceramic evidence that Eu(3+) ions mainly oc

1% Eu(3+) doped glass ceramic evidence that Eu(3+) ions mainly occupy the Y(3+) sites. (C) 2010 American Institute of Physics. [doi:10.1063/1.3402458]“
“Objective. The aim of this study was to evaluate the levels of interleukin (IL)-1 beta, IL-6, IL-8, IL-11, and tumor necrosis factor (TNF)-alpha in temporomandibular joint (TMJ) synovial fluid of the patients with internal derangement

before and 2 weeks after arthrocentesis.

Study design. Forty TMJs of 35 patients (29 females and 6 males, mean age 22.9 years) were included to the study. TMJs were divided into 2 groups: disc displacement with reduction (Group 1, n = 24) and disc displacement without reduction (Group 2, n = 16). Synovial fluid samples were obtained before and 2 weeks after arthrocentesis. IL-1 beta, IL-6, IL-8, IL-11, and TNF-alpha concentrations were measured by using learn more specific kits.

Results. Two weeks after the arthrocentesis procedures, all cytokines were found to be significantly decreased (P < .05) both in Group 1 and Group 2. The difference between 2 groups was insignificant (P > .05).

Conclusion. Arthrocentesis is an

effective technique for eliminating the studied cytokines from the TMJ synovial fluid. (Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2009;107:e1-e4)”
“Objective-To evaluate the effect of IV buy Prexasertib administration of polymyxin B on clinical and serum biochemical variables in foals with experimental endotoxemia.

Design-Prospective experimental

MI-503 supplier study.

Animals-14 healthy neonatal foals.

Procedures-Foals were randomly assigned to a treatment or control group and were administered a single dose of lipopolysaccharide (0.5 mu g/kg 10.23 mu g/lb]) IV over 30 minutes. The treatment group received polymyxin B (6,000 U/kg [2,727 U/lb], IV) immediately after completion of lipopolysaccharide infusion; the control group was administered an equal volume of saline (0.9% NaCl) solution. Subsequent doses of polymyxin B or saline solution were administered IV at 8 and 16 hours. Blood was collected at various time points, and outcome variables, including heart rate, respiratory rate, rectal temperature, attitude score, WBC count, neutrophil count, lymphocyte count, monocyte count, platelet count, Hct, blood lactate concentration, blood glucose concentration, serum tumor necrosis factor-alpha concentration, and plasma thromboxane B-2 concentration, were measured. Urine was collected prior to and after experimentation to determine whether nephrotoxicosis was associated with treatment.

Results-The treatment group had significantly lower blood lactate concentration and serum tumor necrosis factor-alpha and plasma thromboxane B-2 concentrations and had higher blood glucose concentrations and better attitude scores, compared with the control group, at various time points during the study. No other significant differences and no evidence of overt nephrotoxicosis were detected.

Between 2003 and 2010, 73 of 133 patients diagnosed with cervical

Between 2003 and 2010, 73 of 133 patients diagnosed with cervical spondylotic myelopathy and/or radiculopathy treated by TDR experienced atypical symptoms before surgery. The mean follow-up was 34.6 months. There were 47 males and 26 females (mean age 48.9 years). Of the 73 patients, 41 were diagnosed with myelopathy; 13 with radiculopathy; Combretastatin A4 in vivo and 19 with mixed-type spondylosis. The incidence of

each symptom before surgery was dizziness (46.6 %), tinnitus (41.1 %), facial flushing and sweating (41.1 %), palpitations (39.7 %), headache (35.6 %), hypomnesia (30.1 %), nausea and vomiting (20.5 %), blurred vision (20.5 %), and gastroenterologic discomfort (5.5 %). The severity of the following symptoms improved after surgery: dizziness (p = 0.000, alpha = 0.05), headache (p = 0.000, alpha = 0.05), nausea and vomiting (p = 0.000, alpha = 0.05), blurred vision (p = 0.004, alpha = 0.05), tinnitus (p = 0.000, alpha = 0.05), palpitations (p = 0.000, alpha = 0.05), hypomnesia (p = 0.010, alpha = 0.05), and other symptoms (p = 0.030, alpha = 0.05). The gastroenterologic discomfort did not improve (p

= 0.731, alpha = 0.05).

TDR may have a positive effect on atypical symptoms associated with cervical spondylotic myelopathy and/or radiculopathy.”
“The objective of this study was to determine the impact buy ACY-1215 of family income and sickle cell disease on the health-related quality of life (HRQL) of children.

This was a cross-sectional study of children with and without sickle cell disease. Participants completed the PedsQL (TM) generic core scales parent-proxy or child self-report questionnaire during a routine clinic visit. HRQL was the primary outcome measured. CYT387 datasheet Family income and sickle cell disease were the primary independent variables of interest.

A total of

104 children with sickle cell disease and 74 without disease participated in the study. After adjusting for family income, patient age, and the presence of co-morbidities, children with severe sickle cell disease had increased odds of worse overall HRQL (parent-proxy HRQL report odds ratio [OR] 4.0) and physical HRQL (parent-proxy report OR 5.67, child self-report OR 3.33) compared to children without sickle cell disease.

Children with sickle cell disease have significantly impaired HRQL, even after considering the potential detrimental effect of family income on HRQL. Targeted interventions to improve these children’s HRQL are warranted.”
“Purpose of review

Treatment of rheumatoid arthritis (RA) requires strategies for treatment timing and treatment choices. To help rheumatologists choose the right treatment at the right time, this review describes recent trial outcomes, and studies into possible predictors for treatment strategy outcomes.

Recent findings

Very early treatment with abatacept was clinically effective, but prevention of RA or remission induction has not been achieved.

The wettability and IDR of all amorphous samples was found to be

The wettability and IDR of all amorphous samples was found to be higher than the crystalline samples. In conclusion, commercial ATC samples exhibited diverse solid state behavior that can impact the performance and stability of the dosage forms.”
“Objectives: The objective of this study was to investigate the potential clinical roles of circulating soluble interleukin (IL)-6 receptor (sIL-6R) and IL-6R expression on CD4+ T cells (CD4+ IL-6R+ T cells) in chronic hepatitis B (CHB) patients.

Methods: One hundred and thirty-three subjects, including 72 CHB patients, 27 asymptomatic carriers, eight acute

hepatitis B (AHB) patients, and 26 healthy donors were included in this study. Plasma IL-6 and sIL-6R levels were measured by enzyme-linked immunosorbent assay (ELISA); the frequency of CD4+ IL-6R+ T cells was detected by flow cytometry analysis.

Results: GSK2879552 Our data showed a significant increase in plasma sIL-6R levels and the frequency of CD4+ IL-6R+ T cells in peripheral blood in CHB patients compared to asymptomatic carriers and healthy

controls (both p < 0.05). The elevated prevalence of CD4+ IL-6R+ T cells was positively associated with increased serum alanine aminotransferase levels in CHB patients (r = 0.316, p = 0.007), but was not correlated with serum hepatitis B virus (HBV) DNA load. Moreover, CHB patients with an HBV DNA load >1.0 x 10(6) copies/ml had a lower level of plasma sIL-6R than those with an HBV DNA load <1.0 x 10(6) copies/ml.

Conclusions: Sapanisertib Circulating Selumetinib sIL-6R and CD4+ IL-6R+ T cells were increased in CHB patients. Elevated plasma sIL-6R is probably associated with HBV elimination, and CD4+ IL-6R+ T cells in peripheral blood might contribute to the pathogenesis of liver injury in CHB patients. (C) 2011 International Society for Infectious Diseases. Published by Elsevier Ltd. All rights reserved.”
“We have successfully aligned/dispersed the rod and spherical-shaped Si3N4 nanoparticles in the polypropylene (PP)

fibers through melt extrusion process to fabricate polymer nanocomposite (PNC) single fibers. The alignment/dispersion of Si3N4 nanoparticles in PP/Si3N4 PNC fibers has been carried out in a systematic manner to produce uniform single fibers. The PNC fibers were first uniformly stretched and stabilized using a two-set Godet machine. The as-extruded single PNC fibers were tested for their thermal and tensile properties. The test results of PNC fibers were compared to neat PP polymer single fibers fabricated using the same procedure as PNC fibers. These results show that the PNC fibers are much (307%) higher in tensile strength and modulus (>1000%) when compared with the neat PP polymer single fibers. The field emission scanning electron microscope results clearly show the alignment of rod-Si3N4 nanoparticles in polymer matrix.

Mass spectrometry or 2D gel-electrophoresis have evolved greatly

Mass spectrometry or 2D gel-electrophoresis have evolved greatly within recent years and are capable of analyzing multiple proteins or peptides in parallel with high sensitivity and specificity. However, transmission of screening results from one laboratory to another is still the main pitfall of those methods; a fact that emphasizes the need for consistent mTOR inhibitor and standardized procedures as suggested by

the Human Proteome Organization (HUPO). In this article, recent results in screening approaches and other proteomic techniques used for biomarker evaluation in bladder cancer are discussed with a focus on serum and tissue biomarkers.”
“Background: There is currently much interest in the use of decompressive for the management of diffuse cerebral swelling after trauma. Although the use of the

procedure may improve survival, some of those survivors may be left severely disabled. The aim of this study was to see whether severe disability can be predicted and discuss the difficult ethical issue that this raises.

Methods: This was a retrospective cohort subgroup analysis of those patients with severe head injury in Western Australia between 2004 and 2008 who had had a decompressive craniectomy for intractably raised intracranial pressure despite maximal medical management.

Results: Among a total of 1,786 adult neurotrauma patients admitted between 2004 and 2008, 74 patients required a bifrontal decompressive craniectomy for intractably raised intracranial

pressure. After the application of Corticosteroid Randomization https://www.selleckchem.com/products/DAPT-GSI-IX.html After Significant Head Injury (CRASH) trial collaborators’ prediction model, predicted and observed outcomes were compared. The mean CHIR-99021 PI3K/Akt/mTOR inhibitor timing and median timing of surgery were 42 hours and 30 hours after hospital admission, respectively. The timing of decompressive craniectomy was inversely correlated to the severity of the head injury (Spearman’s correlation coefficient = -0.251, p = 0.031). At 18-month follow-up, 16 patients were deceased, 3 were in a persistent vegetative state, and 10 were severely disabled. In contrast to these unfavorable outcomes, 35 patients had a good outcome and 10 were moderately disabled at 18 months. The discrimination of the CRASH prediction model was excellent (area under receiver-operating characteristic curve, 0.905; 95% confidence interval, 0.829-0.982; p = 0.001).

Conclusion: Our data provide some evidence that the CRASH prediction model may help clinicians and families to make informed decision about the benefits and risks of decompressive craniectomy for diffuse cerebral swelling.”
“Background The purpose of this investigation was to evaluate an association between duration of exclusive breastfeeding and structure of cortical regions implicated in general intelligence.

Results: The mean overall response and the mean frequency-specifi

Results: The mean overall response and the mean frequency-specific response levels were lower in the neonates in the study group (p < 0.001). The mean difference between the groups

was 2.47 dB sound pressure level (95% confidence interval: 1.47-3.48).

Conclusions: Maternal smoking during pregnancy had a negative effect on cochlear function, as determined by otoacoustic emissions testing. Therefore, VX-680 concentration pregnant women should be warned of this additional hazard of smoking. It is important that smoking control be viewed as a public health priority and that strategies for treating tobacco dependence be devised. (C) 2011 Elsevier Ireland Ltd. All rights reserved.”
“The goal of this study was to develop an in vivo sonothrombolysis model for stroke research. The rabbit carotid artery has average vessel diameters similar to human M1/M2 segments and allows generation of a thrombotic occlusion using various kinds of thrombus material as well as thrombus placement under visual control.

It further allows real-time monitoring of flow and clot mechanics during the sonothrombolysis procedure using high-frequency diagnostic ultrasound. In the present study, the model will be introduced and first results to show feasibility using diagnostic as well as high-intensity focused ultrasound will be presented.”
“This study aimed to investigate the effect of male semen quality, occupational exposure, and lifestyle on recurrent pregnancy loss (RPL).

Information on couples’ occupational exposure and lifestyle was collected using a detailed questionnaire CAL-101 from 68 RPL couples and 63 randomly selected healthy controls. Semen parameters were estimated by computer-assisted sperm analysis, and sperm nuclear status was detected with aniline blue (AB) staining.

Patients in the RPL group had significantly lower viability, normal morphology, and

total progressive motility of sperm, and a higher mean percentage of AB staining positive sperm compared with those of controls (P < 0.05). There were no differences in sperm concentration, CYT387 JAK/STAT inhibitor and motility between the groups (P > 0.05). Significant odds ratio (OR) was found when occupational exposure and unhealthy habits were superimposed (OR: 11.965, P = 0.005).

In addition to standard female factors for evaluating the risk for RPL, the use of male factors should also be taken into consideration. We found that sperm quality, occupational exposure, and lifestyle are factors that affect RPL. Consequently, occupational exposure and lifestyle factors should constitute an important section of questionnaires given to patients, and these factors should be evaluated by a clinician or trained staff.”
“OBJECTIVES: Herpes zoster has been widely described in the context of different systemic autoimmune diseases but not dermatomyositis/polymyositis.

The cause of the poorer outcomes in cardiac retransplant patients

The cause of the poorer outcomes in cardiac retransplant patients is unclear.

Methods: P505-15 in vitro This study was a retrospective analysis of 859 adult cardiac transplant patients. Of these, 45 (5.7%) under-went cardiac retransplantation at 8.2 +/- 5.3 (mean +/- SD) years after the first transplant, primarily for severe transplant vasculopathy (n = 42).

Results: One-year survival for retransplant patients was significantly lower compared

with de novo transplant patients. (75% vs 87%; P < 0.003). Twenty-three patients died due to either malignancy (n = 8), infection (n = 6), rejection (n = 3), sudden death (n = 2), recurrent transplant coronary artery disease (n = 2) or post-operative bleeding (n = 1).

Conclusion: Although cardiac retransplantation has immediate life-saving benefits, survival is lower compared with de novo cardiac transplantation due to higher rates of malignancy and infection. J Heart Lung Transplant 2009;28:1072-74. Copyright (C) 2009 by the International Society for Heart and Lung Transplantation.”
“The photon absorption in Si quantum dots (QDs) embedded in SiO(2) has been systematically

investigated by varying several parameters of the QD synthesis. Plasma-enhanced chemical vapor deposition (PECVD) or magnetron cosputtering (MS) have been used to deposit, upon quartz substrates, single layer, or multilayer structures of Si-rich-SiO(2) (SRO) with different Si content (43-46 at. %.). SRO samples have been annealed for I h in the 450-1250 this website degrees C range and characterized by optical absorption measurements, photoluminescence analysis, Rutherford Nepicastat backscattering spectrometry and x-ray Photoelectron Spectroscopy. After annealing up to 900 degrees C SRO films grown by MS show a higher absorption coefficient and a lower optical bandgap (similar to 2.0 eV) in comparison with that of PECVD samples., due to the lower density of Si-Si bonds and to the presence of nitrogen

in PECVD materials. By increasing the Si content a reduction in the optical bandgap has been recorded, pointing out the role of Si-Si bonds density in the absorption process in small amorphous Si QDs. Both the photon absorption probability and energy threshold in amorphous Si QDs are higher than in bulk amorphous Si, evidencing a quantum confinement effect. For temperatures higher than 900 degrees C both the materials show an increase in the optical bandgap due to the amorphous-crystal line transition of the Si QDs. Fixed the SRO stoichiometry, no difference in the optical bandgap trend of multilayer or single layer structures is evidenced. These data can be profitably used to better implement Si QDs for future PV technologies. (C) 2009 American Institute of Physics. [doi:10.1063/1.3259430]“
“The purpose of the present study was to analyze the longer-term results for a previously reported cohort of patients who were managed with cementless acetabular fixation at the time of revision arthroplasty.

The current review provides an up-to-date and comprehensive summa

The current review provides an up-to-date and comprehensive summary of the evidence regarding the effectiveness of psychosocial interventions in women with gynaecological cancers.

Methods: Relevant studies

were identified via Medline, CINAHL, and PsycINFO databases (1980 to June 2008), reference lists of articles and reviews, grey literature databases, and consultations with physicians and other experts in the IPI-145 Angiogenesis inhibitor field. Only controlled trials comparing a psychosocial intervention with a control group in a gynaecological cancer population, with at least one quality of life variable as a main outcome, were included in the review. Two authors independently assessed trial quality and extracted data.

Results: Twenty-two studies involving 1926 participants were included. There was substantial variability in study quality and results. Evidence was mixed regarding intervention effects on social and sexual functioning, distress, depression, anxiety, attitude to medical care, self-esteem and body image. Interventions generally

did not improve physical or vocational outcomes.

Conclusions: There was limited evidence in support of healing touch, whereas information-based interventions seemed largely unable to provide meaningful benefits. Cognitive-behavioural interventions had some positive effects. Counselling appeared to be the most promising intervention strategy for addressing quality of life concerns for women with gynaecological cancers. Copyright (C) 2008 John Wiley & Sons, Ltd.”
“This study investigated if metabolomic profiling of culture media using near infrared (NIR) spectroscopy was related to live-birth selleck kinase inhibitor rates after single-embryo transfer of frozen-thawed embryos. Analysis of culture PARP inhibitor media of frozen-thawed embryos was performed by NIR spectroscopy. A viability score was calculated using a predictive multivariate algorithm of fresh day-5 embryos with known pregnancy outcomes. This algorithm generated with fresh day-5 embryos could help to identify the live-birth group from the no live-birth group. Multivariable regression

models that tested the predictive ability of the viability score for live birth showed an odds ratio in the crude analysis of 1.50 (P = 0.008), after adjustment for embryo morphology, 1.44 (P = 0.022), and after adjustment for all variables, 1.71 (P = 0.005); based on a 0.1 step increase in viability scores. In conclusion, higher viability scores resulted in higher live-birth rates. An algorithm generated from fresh embryos might be used to predict viability of frozen-thawed embryos. Frozen-thawed embryos have different metabolic activity which is related to implantation potential. Therefore, this method might be useful to select the best embryo for transfer within a group of embryos with similar morphology. (C) 2011, Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved.

The morphology of eroded surfaces was examined by using scanning

The morphology of eroded surfaces was examined by using scanning electron microscopy (SEM) and their possible erosion mechanisms are discussed. (C) 2011 Wiley Periodicals, Inc. J Appl Polym Sci 123: 1698-1707, 2012″
“The

impact of ectomycorrhiza formation on the secretion of exoenzymes by the host plant and the symbiont is unknown. Thirty-eight F-1 individuals from an interspecific Populus deltoides (Bartr.)xPopulus trichocarpa (Torr. & A. Gray) controlled cross were inoculated with the ectomycorrhizal fungus Laccaria bicolor. The colonization of poplar roots by L. bicolor dramatically modified their ability to secrete enzymes involved in organic matter breakdown or organic phosphorus mobilization, such as N-acetylglucosaminidase, beta-glucuronidase, cellobiohydrolase, Hedgehog inhibitor beta-glucosidase, beta-xylosidase, check details laccase, and acid phosphatase. The expression of genes coding for laccase, N-acetylglucosaminidase, and acid phosphatase was studied in mycorrhizal and non-mycorrhizal root tips. Depending on the genes, their expression was regulated upon symbiosis development. Moreover, it appears that poplar laccases or phosphatases contribute poorly to ectomycorrhiza metabolic activity. Enzymes secreted by poplar roots were added to or substituted by enzymes secreted by L. bicolor. The enzymatic activities expressed in mycorrhizal roots differed significantly

between the two parents, while it did not differ in non-mycorrhizal roots. Significant differences were found between poplar genotypes for https://www.selleckchem.com/products/chir-99021-ct99021-hcl.html all enzymatic activities measured on ectomycorrhizas except for laccases activity. In contrast, no significant differences were found between poplar genotypes for enzymatic activities of non-mycorrhizal root tips except for acid phosphatase activity. The level of enzymes secreted by the ectomycorrhizal root tips is under the genetic control of the host. Moreover, poplar heterosis was expressed through the enzymatic

activities of the fungal partner.”
“Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, amyotrophic lateral sclerosis, and Friedreich’s ataxia are the most common human neurodegenerative diseases pathologically characterized by a progressive and specific loss of certain neuronal populations. The exact mechanisms of neuronal cell death in these diseases are unclear, although some forms of the diseases are inherited and genes causing these diseases have been identified. Currently there are no effective clinical therapies for many of these diseases. The recently acquired ability to reprogram human adult somatic cells to induced pluripotent stem cells (iPSCs) in culture may provide a powerful tool for in vitro neurodegenerative disease modeling and an unlimited source for cell replacement therapy.

It is shown that the calculations of the electronic, structural,

It is shown that the calculations of the electronic, structural, and elastic properties of these structures, using local density approximation (LDA) and generalized gradient approximation (GGA) coupled with projected augmented-wave (PAW) pseudopotentials, agree well with experiments.

A thermodynamic model, which considers the vibrational and electronic contributions to the total free energy of the system, was used to investigate the finite-temperature thermodynamic properties of this website Ti(2)AX. The vibrational contribution was calculated using the supercell method, whereas the electronic contribution resulted from one-dimensional integration of electronic density of states (DOSs). To verify the model, the specific heats of pure elements were calculated and compared to experimental data. check details The DFT-D2 technique was used to calculate the heat capacity of graphite, taking into account the van der Waals (vdW) effect. Good agreement between the calculations and experiments for the specific heats of graphite and other pure elements lends validity to the approach used. The calculated results for the specific heats of Ti2AlC and Ti2AlN match well with experimental data. These strengthen the results of specific

heats of Ti2GaC and Ti2GaN as well as other calculated thermodynamic properties, including the energies of formation and thermal expansion coefficient. (C) 2011 American Institute of Physics. [doi:10.1063/1.3652768]“
“We describe a case of left temporal

lobe epilepsy without hippocampal atrophy. A 31-year-old woman presented with typical symptoms of complex partial seizures. Magnetic resonance see more imaging demonstrated slightly obscure internal structures in the left hippocampus. Scalp electroencephalography revealed interictal epileptiform discharges in the left temporal lobe. A Wada test with propofol determined the language-dominant hemisphere to be the left. Intraoperative electrocorticography revealed active epileptic discharges in the hippocampus and the anterior temporal basal area. The hippocampal epileptic area was treated with multiple transection, which led to the complete cessation of epileptic discharges. After surgery, the Rey Auditory Verbal Learning Test score decreased from 12 to 9. However, it returned to the preoperative level 6 months after surgery. We describe this case as a typical example demonstrating the efficacy of hippocampal transection for seizure control and the preservation of verbal memory. (C) 2011 Elsevier Inc. All rights reserved.”
“We performed a cross-sectional study in 450 nonreferred preschool children aged 4 to 6 years to assess the association between hyperactivity/inattention with adiposity and lifestyle characteristics. Measurements included scores of hyperactivity/inattention, adiposity, objectively measured physical activity, television viewing, and eating habits.

At 10 years of age (7 years after the first clinical event), she

At 10 years of age (7 years after the first clinical event), she developed progressive cognitive deterioration, mood disorder, and headache, suggesting a secondary progressive form of multiple sclerosis. Magnetic resonance imaging and cerebrospinal fluid analysis were equivocal while visual evoked potentials https://www.selleckchem.com/products/CAL-101.html were the sole test in favor of a diagnosis of multiple sclerosis. A multifaceted approach may be needed when dealing with atypical cases

of demyelinating disease in young children.”
“Background: In inflammatory bowel disease a defective mucosal barrier, a dysregulated immune response and an excessive reactivity against the gut microbiota are assumed to cause a breakdown of the intestinal homeostasis and lead to chronic inflammation. Piroxicam treatment is a method for induction of colitis in IL-10 k.o. mice, which integrates a dysfunction

of both the intestinal barrier and the immune system. However, the translational value of this model has not been thoroughly clarified.

Aim: To characterise the piroxicam-accelerated colitis (PAC) IL-10 k.o. model with respect to clinical features, pathogenic mechanisms and its ability to respond to existing therapies.

Methods: The PAC IL-10 k.o. model was established on a C57BL/6 J background and the clinical manifestations, immunological mechanisms and efficacy of ampicillin and anti-IL-12/23p40 treatment were assessed.

Results: The PAC IL-10 k.o. mice developed weight loss and find more diarrhoea, and colonoscopy revealed a thickened granulomatous

mucosa. Histological evaluation of ileum and colon showed Crohn’s disease-like changes with pronounced hyperplasia and focal transmural inflammation. Ileitis was also observed in piroxicam treated wild type mice. The total number of neutrophils, monocytes and natural AZD7762 in vivo killer cells was elevated in the blood compared to IL-10 k.o. and wild type mice, indicating a role of the innate immune system in the pathogenesis. These findings were supported by analyses of the intestinal cytokine profile. Ampicillin and anti-IL-12/23p40 treatment significantly suppressed disease in the model.

Conclusion: The PAC IL-10 k.o. model resembles several features of Crohn’s disease and could be a useful in vivo model in preclinical research. (C) 2013 European Crohn’s and Colitis Organisation. Published by Elsevier B.V. All rights reserved.”
“The static and dynamic magnetic properties of Fe-SiO2 multilayers fabricated onto Si(100) substrates by a radio frequency sputter-deposition system are investigated as functions of deposition angle and Fe thickness. By changing the oblique deposition angle, one can effectively tune the ferromagnetic resonance frequency from 1.7 to 3.5 GHz.